@article{APS5314,
author = {Zhen-jun Zhao and Tong-xun Ma},
title = {Changes in degranulation and histamine release from mast cells in rats sensitized by penicilloyl-protein},
journal = {Acta Pharmacologica Sinica},
volume = {10},
number = {1},
year = {2016},
keywords = {},
abstract = {In this paper, the mechanism of the penicillin G anaphylactic reaction was studied. Rats were sensitized to penicilloyl (BPO)-protein. The incidences of anaphylactic reaction and death were 100 and 40%, respectively. After being challenged, the degranulation rates of rat cranial periosteous and peritoneal mast cells were 91 +/- 5 and 44 +/- 10%, respectively. In the control group, they were 11 +/- 5 and 7 +/- 2%, respectively. The histamine release rates from sensitized and control rat peritoneal mast cells were 13 +/- 2 and 3.0 +/- 0.4%, respectively. The passive cutaneous anaphylaxis (PCA) test demonstrated that the antibody titers in sensitized serum were 16-32.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5314}
}