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Effects of ginsenosides on release of [3H]norepinephrine from rat vas deferens and portal vein

   
@article{APS5299,
	author = {Qi-xin Zhou and Chun-sheng Xue and Ding-nian Wang and Yu-juan Zhang and Li-jia Gao and Ming-hui Chen},
	title = {Effects of ginsenosides on release of [3H]norepinephrine from rat vas deferens and portal vein},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The effects of ginsenosides (G) on the release of [3H]norepinephrine ([ 3H]NE) from the isolated rat vas deferens (RVD) and portal vein (RPV) preloaded with [3H]NE were studied, G (100 micrograms/ml) did not affect the spontaneous or high potassium (H-K+, 60 mmol/L)- and tyramine (Tyr 10 mumol/L)-evoked release of [3H]NE, but obviously blunted the phentolamine (Phe 10 mumol/L)-induced increase in [3H]NE release from RVD and enhanced the isoprenaline (Iso 0.1 mumol/L)-augmented [3H]NE release from RPV evoked by H-K+. It is still not known whether G can bind with adrenoceptors. We infer that G may act as a modulator in sensitizing both presynaptic alpha 2- and beta-receptors.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5299}
}