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Effects of cerebral GABA level on learning and memory

   
@article{APS5293,
	author = {Shi-shan Zhang and Tong-jun Zhu and Dan-shen Zhang and Xing-yan Chen},
	title = {Effects of cerebral GABA level on learning and memory},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {In step-down tests, icv GABA 0.1 micrograms (3 min before training) or ip amino-oxyacetic acid 20 mg/kg (1.5 h before training) both significantly impaired memory acquisition in mice. But semicarbazide (ip 110 mg/kg 3.5 h before training), an inhibitor of GABA synthesis, improved the anisodine-induced impairments of learning. The effects of GABA was also enhanced by aminooxyacetic acid. The results suggest that the increase of cerebral GABA contents is unfavourable to learning and memory.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5293}
}