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Antitumor effects of different combinations of oridonin, bleomycin A5 and nitrocaphane

   
@article{APS5284,
	author = {Tan-mu ZHANG and Ma-gang SHOU and Mian-ying WANG},
	title = {Antitumor effects of different combinations of oridonin, bleomycin A5 and nitrocaphane},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {The antineoplastic effects of the combinations of oridonin (Orid 7.5 mg/kg+bleomycin A5 (BLM, 1.5 mg/kg+nitrocaphane NC, 0.5 mg/kg) and Orid+BLM on the tumor-bearing mice (sarcoma 180, Ehrlich ascetic carcinoma and leukemia P388) were synergistic as compared with the same dose of either Orid, BLM, NC alone or other combinations. Orid +BLM+MC increased the life span (IS) by 264% in S180-bearing mice and Orid+BLM in ILS by 129% in EAC-bearing mice and 120% in P388-bearing mice. The inhibitory rate of S180 in vivo treated with Orid (7.5 mg/kg), BLM (1.0 mg/kg) and Orid+BLM were 52,44, and 83%, respectively. Orid (1 microg/ml)+BLM (40 microg/ml)+NC (32 microg/ml) and Orid+BLM had a greater cytocidal effect on EAC cells in vitro than either drug alone or other combinations.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5284}
}