TY  - JOUR
AU  - Wang Yi-xiong
AU  - Miao Xiao-chun
PY  - 2016
TI  - Effects of L-valyl-valine anhydride on the blood-perfused canine sinoatrial node and papillary muscle
JF  - Acta Pharmacologica Sinica; Vol 7, No 5 (September 1986): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - Experiments were conducted on the canine sinoatrial node and the papillary muscle preparation perfused with the arterial blood from the donor dog through the cannulated sinus node artery and the anterior septal artery.L-valyl-valine anhydride 0.3,1,3,10 microg ia decreased sinus rate 0.2+/-2,10+/-6,21+/-12 beats/min,the artial muscle contractile force 4+/-5,16+/-20,33+/-8,49+/-9% and papillary muscle contractile force 9+/-4, 12+/-4,17+/-10,32+/-25%, respectively. The coronary blood flow did not change significantly. These antagonistic effects on isoproterenol are similar to those on propranolol.  Keywords：L-valyl-valine anhydride; propranolol;isoproterenol;sinoatrial node; papillary muscle; myocardial contraction;heart rate
UR  - http://www.chinaphar.com/article/view/5276