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Alpha-adrenoceptor blocking effect of berberine in isolated rat anococcygeus muscles and rabbit aortic strips

   
@article{APS5266,
	author = {Lai-yuan LUO and Bin CHENG and Da-chao FANG and Ming-xing JIANG},
	title = {Alpha-adrenoceptor blocking effect of berberine in isolated rat anococcygeus muscles and rabbit aortic strips},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {The cumulative dose-response curve for phenylephrine was shifted to the right parallelly by berberine (0.3, 1 an 3 micromol/L) and prazosin (0.01, 0.03 and 0.1 micromol/L) without change in the maximal response. The pA2 values of berberine in the 2 preparations were 6.6 and 6.5, respectively. The results indicate that beberine, like prazosin, shows a competitive alpha-adrenoceptor blocking action.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5266}
}