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Mathematical study on characteristics of average steady-state for drugs obeying Michaelis-Menten elimination kinetics

   
@article{APS5260,
	author = {Huai-wu ZHOU},
	title = {Mathematical study on characteristics of average steady-state for drugs obeying Michaelis-Menten elimination kinetics},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Some equation with regard to average plasma concentrations [1-4], and the time to reach steady-state [7] were derived. The relationship between the bioavailability and area under the plasm concentration-time curve, and the relationship between the average clearance and dose, were described. The parameters applied to clinical drug therapy and the method to estimate them were suggested [20-22], and the concept of “bioavailable efficiency” was introduced.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5260}
}