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Influences of propranolol on uptake and loss of norepinephrine in tissues of rats

   
@article{APS5248,
	author = {De-Zai Dai and Jian Ge and Li-Hua Zhang and Ling Jin},
	title = {Influences of propranolol on uptake and loss of norepinephrine in tissues of rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Propranolol 12.5 mg/kg was injected sc bid for 2 or 9 d in rats. The uptake rate of [3H]norepinephrine ([3H]NE) was markedly accelerated in the heart, spleen, lungs, and adrenal glands. The enhancements ranged from 182 to 285% and sustained throughout the period of medication. The releasing rate constant K of [3H]NE in these tissues increased in the d-2 group. The K values of lungs and spleen decreased in the d-9 group. Both the uptake rate and releasing rate constant K showed a sharp fall on the d 2 after the withdrawal of propranolol to or below the control. Chronic medication of propranolol in rats exerted significant effects on the uptake and releasing rate constants in the tissues.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5248}
}