@article{APS5238,
author = {Xiu-Juan Cheng and Yu-Lan Liu and Yan-Shen Deng and Gui-Feng Lin and Xiao-Tian Luo},
title = {Effects of ginseng root saponins on central transmitters and plasma corticosterone in cold stress mice and rats},
journal = {Acta Pharmacologica Sinica},
volume = {8},
number = {6},
year = {2016},
keywords = {},
abstract = {The effects of ginseng root saponins (GRS) on the rectal temperature, plasma corticosterone and central transmitters were studied using mice and rats subjected to a cold stress. When mice were put in - 2°C environment for 1 h, the rectal temperature fell significantly. While ig GRS 50 or 100 mg/kg caused a slow fall in rectal temperature of mice in the same condition. The contents of brain NE, 5-HT, 5-HIAA were decreased in mice in -4°C environment for 1 h, and increased in mice after ig GRS 100 mg/kg. But DA showed no change both in cold stress and GRS groups.
When rats were put in -2°C for 1 h, the rectal temperature also fell markedly, the plasma corticosterone increased. While ig GRS 70 mg/kg, the rectal temperature showed no change, the brain ACh and plasma corticosterone increased apparently, but there was no change in brain GABA, Glu and Asp.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5238}
}