@article{APS5213,
author = {Xiao-Dong Liu and Sheng-Kai Huang and Hui-Nan Yuan},
title = {Determination of sophoramine and sophocarpine in rabbit plasma by capillary column gas chromatography and their pharmacokinetics},
journal = {Acta Pharmacologica Sinica},
volume = {8},
number = {5},
year = {2016},
keywords = {},
abstract = {capillary column gas chromatography was proposed. The recovery of sophoramine from plasma was over 90%. There was a linear relationship between 0.5 and 10μg. The comparative pharmacokinetics of sophoramine and sophocarpine (iv 10 mg/kg) were studied in rabbits. Plasma concentration vs time data were described by an open two compartment model. The pharmacokinetic parameters of sophoramine and sophocarpine were as follows: Vc 0.72 and 1.40 L/kg; CL 17.0 and 28.2 ml/(kg·min-1)；α 0.126 and 0.114 min-1；β 0.0136 and 0.00853 min-1, respectively. The differences in distribution volume, clearance and elimination rate constant of the drugs were significant (p},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5213}
}