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Effects of acidic polysaccharide from holothuria leucospilota on platelet aggregation in rabbits

   
@article{APS5194,
	author = {Chun-Wen Shan and Qi-Zhao Liang and Qiang-Ji Wang},
	title = {Effects of acidic polysaccharide from holothuria leucospilota on platelet aggregation in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Platelet aggregations induced by acidic polysaccharide from Holothuria leucospilota (Brandt) (HL-P) 2.56-320μg/ ml in vitro and 2 mg/kg iv were observed in rabbits. The results showed that HL-P had no effect on the aggregation of platelet treated with anticoagulants, trisodium citrate or EDTA-Na2, and could mildly induce the aggregation of platelet treated with heparin. A significant proaggregatory effect on blood platelet suspended in modified Tyrode’ s solution was caused by HL-P, and potentiated by Ca2+ and Mg2+. HL-P prompted ADP-induced platelet aggregation to a certain extent. However, HL-P produced a very significant inhibition on thrombin-induced platelet aggregation. The amount of platelets was diminished by HL-P.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5194}
}