@article{APS5149,
author = {Ba-Jin Han and Er-Feng Zhou and Bao-Song Wan and Yun-Zhao Tang and Jia-Mei Yang and Mei-Hua Xie},
title = {Anti-arrhythmic effects of methylflavonolamine hydrochloride},
journal = {Acta Pharmacologica Sinica},
volume = {8},
number = {4},
year = {2016},
keywords = {},
abstract = {Methylflavonolamine hydrochloride (MFA) showed anti-arrhythmic effects on (l) chloroform-induced ventricular fibrillation in mice with therapeutic indices of 4.1 (ip) and 5.3 (iv)； (2) chloroformepinephrine or BaCl2 induced arrhythmias in rabbits： (3) aconitine-induced arrhythmias in rats.
The electrophysiological effect of MFA on the hearts of rabbits were studied by suction electrode method in situ. At the therapeutic dose (5 mg/kg iv), APD50, APD90 and FRP were prolonged by 9.0±3.6 ms, 12.9±4.9 ms and 29.8±5.6ms, respectively.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5149}
}