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Effects of acetylgastrodin on vertebral and internal carotid artery blood flow in anesthetized dogs and rabbits

   
@article{APS5145,
	author = {Zhi-He Chen and Zheng-Xian Zhang and Xin-Hua Wang and Jian-Ming Xiang and Jian-Ming Xiong and Yun-Qiang Mo},
	title = {Effects of acetylgastrodin on vertebral and internal carotid artery blood flow in anesthetized dogs and rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Acetylgastrodin is a derivative of gastrodin which is an effective constituent of Gastrodia elata. In anesthetized dogs and rabbits, the hemodynamics with special reference to cerebral circulation were studied.
  Following intraduodenally administration of acetylgastrodin suspension 200 mg/kg to dogs, the vertebral artery flow increased at 10-60 min (+15-30%, p0.05, n=8). Similarly, the internal carotid flow of rabbits markedly increased (+24-111%, n=8, p0.05, n=8). However, in the same route, nicardipine 250 μg/kg caused a significant increase of internal carotid flow of rabbits (+41-88%, p},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5145}
}