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Effects of ephedrine and its analogs onβ-adrenoceptors of rat lung cell membrane1

   
@article{APS5143,
	author = {Ming-Hua Jiang and Lu Liu and Qiang Wang and Wei-Xiang Zhan and Huai-De Shu},
	title = {Effects of ephedrine and its analogs onβ-adrenoceptors of rat lung cell membrane1},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The affinities of l-ephedrine (l-Eph), d-pseudoephedrine (d-pseudo-Eph), l-methylephedrine (l-Me-Eph) and d-pseudonorephedrine (d-pseudo-nor-Eph) toβ-adrenoceptors were investigated on isolated rat lung cell membranes by ligand binding assay. All the compounds competed with the binding of [3H]dihydroalprenolol to the rat lung cell membrane preparations. The orders of affinity toβ-adrenoceptors were: l-Eph>d-pseudo-nor-Eph >d-pseudo-Eph>l-Me-Eph. The action of l-Eph to activate the adenyl cyclase (AC) was greater than those of d-pseudo-Eph and l-Me-Eph, which appeared to be consistent with the orders of affinity toβ-adrenoceptors. The facts that d-pseudo-nor-Eph has no effect on AC activity and antagonizes the stimulating action of isoproterenol on AC activity suggest that d-pseudo-nor-Eph is aβ-adrenoceptor blockader.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5143}
}