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Evidence for major pleiotropic effects on bone size variation from a principal component analysis of 451 Caucasian families

   
@article{APS5128,
	author = {Li-jun Tan and Yao-zhong Liu and Peng Xiao and Fang Yang and Zi-hui Tang and Peng-yuan Liu and Robert R Recker and Hong-wen Deng},
	title = {Evidence for major pleiotropic effects on bone size variation from a principal component analysis of 451 Caucasian families},
	journal = {Acta Pharmacologica Sinica},
	volume = {29},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Aim: To identify pleiotropic quantitative trait loci (QTL) influencing bone size (BS) at different skeletal sites in Caucasians.
 Methods: In a sample containing 3899 Caucasians from 451 pedigrees, 410 microsatellite markers spaced ~8.9 cM apart across the human genome were genotyped. Phenotypical and genetic correlations of BS at lumbar spine, hip (femoral neck, trochanter, and intertrochanter regions), and wrist (ultradistal, mid-distal, and one-third distal sites) were determined using bivariate quantitative genetic analysis. A principal component analysis (PCA) was performed to obtain principal component (PC) factors that were then subjected to variance components linkage analysis to identify regions linked to the PC.
 Results: Genetic correlations of BS at different skeletal sites ranged fr om 0.40 to 0.7 9 (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5128}
}