@article{APS5087,
author = {De-Lin Wu and Mei-Yu Jiang and Li-Min Zhang and Jie Sun and Qi Chen},
title = {Metabolism of 125I-superoxide dismutase in mice},
journal = {Acta Pharmacologica Sinica},
volume = {8},
number = {3},
year = {2016},
keywords = {},
abstract = {Mice were injected iv or im with 125I-cuprozinc superoxide dismutase (125I-SOD-1). Radioactive counting of 125I-SOD-1 in blood was highest at 3 min. The absorption and elimination in iv group were faster than in im group. The biological t1/2 were 1.5 and 3.6 h after iv and im, respectively. The bioavailability in the im group was 68.7%. 125I-SOD-1 in plasma was subjected to electrophoresis 3 min after injection, with the amount of degradation in im and iv being 22±4 and 25±12 %, respectively. The tissue distribution of radioactivities were as follows: kidney>lung>adrenal gland.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5087}
}