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Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation

   
@article{APS5075,
	author = {Ling-hua Meng and Jian Ding},
	title = {Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation},
	journal = {Acta Pharmacologica Sinica},
	volume = {28},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {Salvicine is a novel diterpenoid quinone compound obtained by structural modification of a natural product lead isolated from a Chinese herb with potent growth inhibitory activity against a wide spectrum of human tumor cells in vitro and in mice bearing human tumor xenografts. Salvicine has also been found to have a profound cytotoxic effect on multidrug-resisitant (MDR) cells. Moreover, Salvicine significantly reduced the lung metastatic foci of MDA-MB-435 orthotopic xenograft. Recent studies demonstrated that salvicine is a novel non-intercalative topoisomerase II (Topo II) poison by binding to the ATPase domain, promoting DNA-Topo II binding and inhibiting Topo II-mediated DNA relegation and ATP hydrolysis. Further studies have indicated that salcivine-elicited ROS plays a central role in salvicine-induced cellular response including Topo II inhibition, DNA damage, circumventing MDR and tumor cell adhesion inhibition.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5075}
}