@article{APS5072,
author = {Yu-Qun Zheng and Fu-Ben Xu and Shu Zhou and Nai-San Li and Zi-Long Shen and Wei-Jian Chen},
title = {Abortifacient activity of caffeic acid and its antiprogestational action in early pregnant mice},
journal = {Acta Pharmacologica Sinica},
volume = {8},
number = {3},
year = {2016},
keywords = {},
abstract = {Fourteen out of fifteen 6-d pregnant mice were found aborted after ig caffeic acid (CFA) l0 mg/kg bid for 3d. The ED50 of abortifacient effect of CFA was 2.13 (mg/kg bid×3 d). The interceptive action of CFA was counteracted by the simultaneous sc megestrol (MG) 50 mg/kg bid ×3 d, ip hCG 10 IU/(mouse∙d)×3d or ig tiapride 50 mg/kd bid ×4 d.
CFA inhibited significantly the decidual cell reaction (DCR). This effect was no longer observed when MG was given simultaneously. Moreover, CFA had no effect on DCR of the sex-hormone-treated ovariectomized mice. The plasma progesterone level of the pregnant mice decreased markedly after ig CFA.
Histomorphologic examination of the ovaries from aborted or pseudopregnant mice treated by CFA revealed a serious atrophy of the corpora lutea and degeneration and necrosis of the decidual tissue. Even when MG was injected simultaneously, the trivial degeneration of the decidual tissue was still seen.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5072}
}