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Relation of antihypertensive effect and central α-adrenocptor of rhomotoxin

   
@article{APS5071,
	author = {Xing-Jian Chen and Hong-Ying Fan and Yu-Fa Yao and Jia-Xing Zhang and Wei-Xing Gu and Xiao-Ming Liu and Ju-Fang Liu},
	title = {Relation of antihypertensive effect and central α-adrenocptor of rhomotoxin},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Rhomotoxin 8μg/kg iv caused a decrease of arterial blood pressure in rabbits. Small doses 1.2μg/kg also showed antihypertensive effect when injected intracerebroventricularly but not when given intravenously. The antihypertensive effect of rhomotoxin 1.2μg/kg icv was partially antagonized by theα-adrenoceptor blocker phentolamine 50μg icv andα1 blocker prazosin 30μg icv and completely antagonized byα2 blocker yohimbine 50μg icv. The plasma renin activity of rats was suppressed 25.8% by rhomotoxin. These results suggest that the antihypertensive effect of thomotoxin is closely related to centralα2 -adrenoceptors.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5071}
}