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Effects of d-isocorydine on mouse vas deferens

  
@article{APS4969,
	author = {Huai-de SHU and Guo-ping HUANG},
	title = {Effects of d-isocorydine on mouse vas deferens},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {On isolated mouse vas deferens preparations, d-isocorydine hydrochloride (53-212 microM) enhanced the twitch response to field stimulation. However, 424 microM, caused an inhibition. Yohimbine 0.1 microM had no influence on the action of d-isocorydine.
  Verapamil-HCl 4-256 microM showed similar actions as that of isocorydine. On electrically induced twitch responses it revealed an excitation at 4-32 microM but an inhibition at 128-256 microM. Paraverine 1.33-85.1 microM exhibited only inhibitory action on the twitch response to field stimulation.
  Both phasic and tonic contractions of vas deferens induced by norepinephrine and KCl were inhibited by d-isocorydine, papavcrine and verapamil. But the rhythmic contraction triggered by norepinephrine was enhanced by isocorydine. The above-mensioned action was probably nyogenous since.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4969}
}