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Electrophysiological effects of vanilol on isolated papillary muscles of guinea pigs and atrioventricular conduction of rabbits

   
@article{APS4950,
	author = {Ji-Gao Xiao and Xuan-De Li and Tian-Pei Liu},
	title = {Electrophysiological effects of vanilol on isolated papillary muscles of guinea pigs and atrioventricular conduction of rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Vanilol (l-(2-methoxy-4-methoxycarbonyl-1-phenoxy)-3-isopropyl- amino-2-propanol), a derivative of protocatechuic acid with the same side chain as propranolol, could antagonize the experimental arrhythmias. Vanilol 1-100μmol/L caused a depression of Vmax of phase O in isolated papillary muscle cells of guinea pig. Vanilol (0.1, 1, 10μmol/L) prolonged the effective refractory period (ERP), and increased the rate of ERP/APD90, from 0.945±0.017 of control to 0.988±0.015 (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4950}
}