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Antagonism of the neuromuscular blocking effect of polymyxin B by 3,4-diaminopyridine

   
@article{APS4946,
	author = {Xiang-Ming Fang and Yuan-Pei Zhang and Yu-Liang Shi and Wen-Ping Wang},
	title = {Antagonism of the neuromuscular blocking effect of polymyxin B by 3,4-diaminopyridine},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Polymyxin B (0.2 mg/ml) depressed the contractile response of rat diaphragm to indirect stimulation, decreased the amplitude of end-plate potential and blocked the neuromuscular transmission at last. 3,4-Diaminopyridine (0.l mmol/L) antagonized this inhibitory effect. It increased the amplitude of end-plate potential and restored the neuromuscular transmission. The twitch respones recovered immediately after the addition of 3,4-diaminopyridine (0.2 mmol/L) and exceeded its control. However, the antagonistic effect of 3,4- diaminopyridine lasted only 1.5-2 h. The miniature end-plate potential abolished by polymyxin B did not reappear after the administration of 3,4-diaminopyridine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4946}
}