@article{APS4943,
author = {Jie Zhou and Wei-Jun Zheng and Zhi-Qiang Chi},
title = {Analgesic activity and respiratory inhibition of 3-(β-phenylethyl)- 9β-methoxy- 9α- (m-hydroxyphenyI)-3-azabicyclo)-3-3azabicyclo[3,3, 1]-nonane (P-7521 ) in rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {8},
number = {1},
year = {2016},
keywords = {},
abstract = {P-7521 is an azabicycloalkane derivative. When P-7521 was given iv to rabbits, its analgesic ED50 was 0.37μg/kg, the analgesic activity was 427 times as potent as that of morphine, and the duration of analgesic action was double that of morphine. The analgesic dose depressed the respiration slightly. But when doses even as large as 1200×ED50 were given, the respiratory action was never completely depressed, asphyxia and death were not encountered.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4943}
}