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Inhibition of bovine parathyroid hormone-(1-34) on calimycin-induced spontaneous contraction of rat vas deferens

  
@article{APS4938,
	author = {Wu Yang and Xiao-peng Yu and Hui-ying Gao and Zhen-gang Wang},
	title = {Inhibition of bovine parathyroid hormone-(1-34) on calimycin-induced spontaneous contraction of rat vas deferens},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The calcium ionophore calimycin(A-23187, CM)induced spontaneous contractions of the isolated rat vas deferens in dose-related manner closely dependent on calcium concentration in Krebs-bicarbonate solution.The effect of CM(10,50 microM) on this preparation was inhibited by bPTH-(1-34)(0.48, 1.44 nM) and phentolamine(0.1 mM).Phentolamine(10 microM) inhibited the norepinephrine-indcued contraction but bPTH-(1-34) did not. The finding suggest that the inhibitory effect of bPTH-(1-34) on the spontaneous contractions induced by CM may be the result of ioterference with the availability of calcium in releasing endogenous norepinephrine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4938}
}