@article{APS4934,
author = {Yong-yuan Guan and Hua He and Jun-xiu Chen},
title = {Effect of the total saponins of Panax notogiseng on contraction of rabbit aortic strips},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {4},
year = {2016},
keywords = {},
abstract = {The mechanism of vasodilator action of the total saponins of Panax notoginseng(PNS), which was noted in our preceeding work, was studied on isolated rabbit aortic strips. Norepinephrine(NE)-induced contraction response was antagonized by 2*10(-4) and 6*10(-4) g/mL PNS in a non-competitive manner. In Ca++-free Krebs solution, NE only caused initial fast response, which was not influenced by PNS. Ca++-dependant response after addition of Ca++(2.5 mM) was markedly reduced by 6*10(-4) g/mL PNS.In contrast, PNS did not antagonize KCl-induced contraction response. The results indicate that PNS is probably a calcium entryblocker which causes vasodilation by inhibiting adrenoceptor-operated calcium influx.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4934}
}