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Effects of pranolium on action potentials of myocardiac cells and on aconitine-induced arrhythmias

  
@article{APS4930,
	author = {Tai-feng Liu and Jian-heng Wei and Zhong-min Wang and Zhen Chai and Xiao-bo Liu and Xiao-gang Gu},
	title = {Effects of pranolium on action potentials of myocardiac cells and on aconitine-induced arrhythmias},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {In rats pranolium( UM-272, a derivative of propranolol) prevented the arrhythmia induced by iv aconitine 16 microg/kg. Perfusion with 15.6 and 31.2 mg/L on isolated porcine ventricular preparations, the action potential(AP) of the ventricular fiber changed significantly: 1)the amplitude and the maximum rate of depolarization were reduced; 2) the duration and the effective refractory period were prolonged. These results showed that pranolium exhibited the quinidine-like anti-arrhythmic action on myocardium.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4930}
}