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Antagonistic effects of ascorbic acid on caffeine-induced embrotoxic and teratogenic activities in rats

   
@article{APS4918,
	author = {Suo-di ZHAI and Mu-qun CHEN and Li-ping DONG and Xiu-rong JIA},
	title = {Antagonistic effects of ascorbic acid on caffeine-induced embrotoxic and teratogenic activities in rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Caffeine ig 75 mg/kg*7 d in pregnant Wistar rats induced embryo-toxicities and teratogenicities, including early absorption of the feuses, short and curl tails, decreased body weight and length even bone abnormalities, which became more serious under caffeine ig 100 mg/kg. Under the effect of caffeine ig 100 mg/kg+ascorbic acid ig 200 mg/kg or caffeine ig 100 mg/kg+ascorbic acid im 125 mg/kg, all the abnormalities were lessened, similar to that induced by caffeine 75 mg/kg. These results show that ascorbic acid antagonizes the caffeine-induced embryotoxicities and teratogenicities.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4918}
}