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Emesis induced by cisplatin and sulfatol 2-diaminocyclohexaneplatinum in dogs and the antiemetics

   
@article{APS4917,
	author = {Mei-ling HUO and Yuan-shu WANG and Peng WANG and Yong-sheng XIANG and Jian-guo WANG},
	title = {Emesis induced by cisplatin and sulfatol 2-diaminocyclohexaneplatinum in dogs and the antiemetics},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Vomitting was induced in dogs by iv sulfatol 2-diamiocyclohexaneplatinum (SHP) 1.5 mg/kg or cisplatin 3 mg/kg. The upsurge of vomiting appeared 1-2 h after SHP with a total of 10+/-3 emetic episodes while 2.5-3.5 h after cisplatin with a total of 16+/-5 episodes. Metoclopramide (im 1-2 mg/kg*3) +diphenhydramine (im 0.52 mg/kg*3) given 0.5 h before, 1 h and 2.5 h after SHP or cisplatin showed an antiemetic effect better than that of dexamethasone (im 0.13-0.2 mg/kg*3)+haloperidol (im 0.26 mg/kg*3). The dogs after medication showed sedation and sleepness.
It is postulated that the drug combinations that simultaneously block dopamine, muscarinic and histamine receptors in brain could subside the emesis.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4917}
}