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Effects of harringtonine on induced chromosome aberrations and micronuclei

   
@article{APS4914,
	author = {Nian-jun HUANG and Shi-ming CHEN},
	title = {Effects of harringtonine on induced chromosome aberrations and micronuclei},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {The genetic toxicity and carcinogenic potential of harringtonine, a new antineoplastic drug, have been assessed by Chinese hamster lung cell chromosomal aberration test and micronucleus test in mice. Harringtonine induced the dose-dependent chromosomal aberrations in vitro. The highest rate of chromosomal aberrations was 47% at 0.2 microg/mL for 48 h. It also induced nuclear fragmentation of hemocytoblast of bone marrow in mice. The number of micronucleated polychromatic crythrocytes was remarkably increased in 1.8% cells at 1.25 mg/kg for 24 h. Obviously harringtonine showed a genetic toxicity and carcinogenic potential.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4914}
}