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Anti-arrhythmic action of d-isocorydine hydrochloride

   
@article{APS4898,
	author = {De-hua ZHAO and Xiao-min YANG and Bao-heng SHENG},
	title = {Anti-arrhythmic action of d-isocorydine hydrochloride},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {In anesthetized rats, d-isocorydine hydrochloride (ISOC) 5-20 mg/kg iv significantly counteracted the arrhythmias caused by BaCl2 3 mg/kg or aconitine 20 microg/kg iv, and decreased the incidence of ventricular fibrillation and mortality rate caused by CaCl2 120 mg/kg iv. In rabbits, ISOC 10 mg/kg iv abolished the arrhythmias induced by inhalation of chloroform and adrenaline iv. The doses of ouabain necessary to induce ventricular extrasystole, ventricular fibrillation and death were elevated by ISOC 10 mg/kg iv in anesthetized guinea pigs. The functional refractory period (FRP) of myocardial monophasic action potentials in rabbits was prolonged and the heart rate of rats decreased after ISOC 10 mg/kg iv. In vivo, ISOC decreased the contractility, excitability, and automaticity induced by adrenaline and FRP of guinea pig papillary muscle was prolonged, with weaker Ca2+ antagonistic effect.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4898}
}