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Role of carboxylesterase in soman poisoning illustrated indirectly by histochemistry and image-analyzer technique

   
@article{APS4880,
	author = {Xiao-shan XU and Shou-zhong YU and Zhen-sheng ZHANG and Rui-biao YANG},
	title = {Role of carboxylesterase in soman poisoning illustrated indirectly by histochemistry and image-analyzer technique},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {By the technique of cholinesterase (ChE) histochemistry combined with quantitative image-analyzer, it was found that the ChE-inhibited area in sections of mouse liver was increased and the dose of soman (methyl pinacolyl phosphonofluridate) required to intoxicate mice was increased. Sodium Phenobarbital as a carboxylesterase (CE) activator limited the ChE-inhibited area induced by soman; while TOCP (tri-O-cresyl phosphate) as an irreversible CE inhibitor extended the ChE-inhibited area induced by soman. The indirect evidence that CE in mouse liver had a detoxicating action to soman poisoning was consistent with the previous reports by Sterri and Clement.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4880}
}