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Functional subtypes of renal α1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension

   
@article{APS4874,
	author = {A Armenia and Munavvar Abdul Sattar and Nor Azizan Abdullah and Md Abdul Hye Khan and Edward James Johns},
	title = {Functional subtypes of renal α1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension},
	journal = {Acta Pharmacologica Sinica},
	volume = {29},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Aim: This study investigates the subtypes of the α1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats.
Methods: The renal blood flow responses to renal nerve stimulation, noradrenaline, phenylephrine, and methoxamine were measured in the absence and presence of nitrendipine, 5-methylurapidil, chloroethylclonidine and BMY 7378.
Results: The renal vasoconstrictor responses were markedly attenuated by nitrendipine and 5-methylurapidil in the diabetic rats (all P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4874}
}