@article{APS4848,
author = {Xiu-fang Yue and Fu-geng Wu and Bin Xu},
title = {Effect of oxalysine on pulmonary metastases of Lewis lung carcinoma in mice},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {3},
year = {2016},
keywords = {},
abstract = {Oxalysine was found to be an antitumor antibiotic with a simple chemical structure very similar to lysine. In this paper, the antimetastatic action of oxalysine was studied and compared with ICRF-159. The Lewis lung carcinoma-bearing mice were killed at intervals during 10-21 d after sc implantation of tumor. The lungs from these mice were transplanted to other mice to examine the presence of tumor cells by bioassay. On d 21 after implantation of lung the tumor growth was found in 78% of the recipient mice. Oxylysine(160 mg/kg/d) was injected ip for 10 d to the Lewis lung carcinoma-bearing mice. The antimetastatic action could be detected when the treatment was started on the next day after implantation of tumor cells(P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4848}
}