@article{APS4813,
author = {Zhan-rong Li and Jian-bo Feng and Rui Han and Ming-biao Yin and Li-juan Xia},
title = {Effect of aclacinomycin B on DNA polymerase II of tumor cells},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {3},
year = {2016},
keywords = {},
abstract = {DEAE-cellulose, phosphocellulose and DNA-agarose affinity chromatography were used to isolate and purify the DNA polymerase II from L1210 cells and Lewis lung carcinoma. The enzyme showed a single polypeptide band on the profile of non-denaturing polyacrylamide electrophoresis and possessed high sensitively to N-ethylmaleimide(NEM).Aclacinomycin B inhibited potently DNA polymerase II from the 2 sources. The IC50 was 3.6 microg/ 100 microL and 5.3 microg/100 microL for Lewis lung carcinoma and the L 1210 enzymes, repectively.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4813}
}