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Plasma protein-binding rate and saliva concentration of artemether in rabbits

   
@article{APS4804,
	author = {Ya-ping Lou and Zhen-guang Zhang and Han-lin Shu and Yan-lin Zeng},
	title = {Plasma protein-binding rate and saliva concentration of artemether in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {The plasma protein binding rate (fb) determined by equilibrium dialysis amounted to about 93% when the concentration of artemether was 1.1-6.9 microg/mL. The binding parameter beta(4.28 micromol/g) and Kdp(20.3 microM) were obtained by Woolf plot. The concentration of artemether in saliva(S) was directly proportional to that in plasma(P), the linear regression: P=0.960+11.1S. When the concentration of artemether was 1.1-6.9 microg/mL, the S/P ratio was 7±4%, which was very close to the unbound drug % in plasma. It is possible to estimate fb in vivo from S/P ratio.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4804}
}