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Inhibitory effects of non-steroidal anti-inflammatory drugs on the binding of prostaglandins to human serum albumin

   
@article{APS4802,
	author = {Yi-nian Huo and Zhen-gang Wang and Yin-chang Jin},
	title = {Inhibitory effects of non-steroidal anti-inflammatory drugs on the binding of prostaglandins to human serum albumin},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {This paper deals with the influence of some acidic nonsteroidal anti-inflammatory drugs(NSAID)(sodium salicylate, aspirin, indomethacin,ibuprofen and phenylbutazone) and other agents(chlorpromazine, eutonyl, cocaine, procaine, benzocaine, gossypol, etc.) on the binding of [3H]PGE1, [3H]PGF2alpha and [3H]PGA1 to human serum albumin(HAS) determined by equilibrium dialysis. With adequate concentrations(0.1-10 mM) all the acidic NSAID significantly inhibited the binding of the [3H]PG to HSA. The nonanti-inflammatory drugs which inhibited prostaglandin synthesis showed no significant inhibitory activity on prostaglandin binding to HSA.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4802}
}