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Body retention of 169Yb-citrate and its excretion by 4 chelating agents

  
@article{APS4781,
	author = {Shou-peng ZHU and Jing-yong ZHAO and Kun-yuan SU and Qi-zhong MO and Guo-lin WANG},
	title = {Body retention of 169Yb-citrate and its excretion by 4 chelating agents},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {After iv 169Yb-citrate 20 μCi/kg in rats, there was a selective deposition and a high accumulation of 169Yb in skeleton disclosed by a well-type scintillation counting technique. Excretion of 169Yb-citrate was slow. About 20% was excreted from urine and feces in 72h. Both amino carboxylic type chelating agents diethylenetriaminepentaacetic acid (DTPA) and quinamic acid therapy removed large amount of 169Yb-citrate from the body.Polyphosphoric acid type (propyl aminoethylene diphosphoric acid) and sulfhydryl type chelating agents (penicillamine) showed no significant effect.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4781}
}