@article{APS4777,
author = {Paul W FERGUSON and Philip J MEDON and Carl F WATSON},
title = {Effect of aqueous extracts of Acanthopanax senticosus on parathion toxicity in mice},
journal = {Acta Pharmacologica Sinica},
volume = {5},
number = {4},
year = {2016},
keywords = {},
abstract = {Parathion toxicity in♂Swiss-Webster mice was enhanced by ip pretreatment with the aqueous extract (160 mg/kg/d×4d) of the root of Acanthopanax senticosus(AS). On d 5, in vivo RBC AchE was measured before and 30 min after ip parathion(5 mg/kg). In vitro parathion metabolism using the S-9 liver microsomal fraction and in vitro inhibition of RBC AchE by paraoxon were compared for control and AS pretreated mice. RBC AchE prior to parathion was similar to control values from mice not on a pretreatment schedule (280±20 nmol/min/ml RBC). RBC AchE of AS pretreated mice challenged with parathion(160±10 nmol/min/ml RBC) was significantly lower than non AS pretreated mice (250±10 nmol/min/ml RBC). In vitro RBC AchE activity after incubation with paraoxon (0.09 Μm) was similarly inhibited for control (55%) and AS pretreated mice (59%). No significant differences were observed in % of total analytes after a 30 min incubation with S-9 for parathion 66%, 62%), paraoxon (13%, 15%) and p-nitrophenol (21%, 21%) from control and AS pretreated mice, respectively.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4777}
}