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Spinal alpha-adrenoceptor and dynorphin involvement in the depressor effect of clonidine

   
@article{APS4759,
	author = {Cui-wei XIE and Jin-sheng HAN},
	title = {Spinal alpha-adrenoceptor and dynorphin involvement in the depressor effect of clonidine},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Intrathecal injection (ith) of clonidine (1 μg) in rats caused a decrease in the mean blood pressure (-52±12mm Hg,   ±SD) and heart rate (-99±24 beats/min) which were partly antagonized by ith α-adrenoceptor blocker phentolamine (30μg), or the selective α1 or α2-adrenoceptor blocker prazosin or yohimdine (30 μg, respectively). The effects of clonidine was also blocked by opiate antagonist naloxone (10 mg/kg, iv) or by pretreatment with dynorphin antiserum (10μl,ith). Naloxone (0.5 mg/kg, iv) or pretreatment with control serum (10 μl, ith) failed to reduce the effects of clonidine. The results suggest that an activation of α1 and α2-receptors and the release of dynorphin in spinal cord are important for mediating the depressor effect of ith clonidine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4759}
}