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Cardiac and hemodynamic actions effect of total saponins of Panax notoginseng

   
@article{APS4739,
	author = {Jia-dong WANG and Jun-xiu CHEN},
	title = {Cardiac and hemodynamic actions effect of total saponins of Panax notoginseng},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {On pentobarbital anesthetized open-chest cats iv total saponins of Panaxnotoginseng (PNS) 20mg/kg decreased left ventricular pressure (LVP) 23±9%***, decrased blood pressure (BP) 20±9%***, and decreased total peripheral vascular resistance(TPVR) 24±15%**. Heart  rate (HR), left ventricular end diastolic pressure (CVP) did not change significantly. dP/dtmax decreased 20±10%***; t-dP/ dtmax increased 10±5%***. Cardiac stroke work index (LVWI) decreased 21±8%***. Minute tension-time index(TTI/min) decreased 27±15%***. Blood was driven from carotid into femoral artery in cats by a peristaltic pump. PNS iv decreased femoral artery resistance with a lag time just the same as that required to pass through the delay circuit. In dog heart-lung preparation, depressant effect on cardiac pump was observed.(**p},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4739}
}