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Adaptive effect and withdrawal syndrome of propranolol in relation to norepinephrine and epinephrine

   
@article{APS4730,
	author = {De-zai Dai and Jin-zhou Xie and Chun-fang Liu and Zhen-nan Wang},
	title = {Adaptive effect and withdrawal syndrome of propranolol in relation to norepinephrine and epinephrine},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Two distinct phases of changes in the urinary and myocardial norepinephrine (NE) were observed in rats after sc injection of propranolol * 7d. The first phase was up-regulation of NE. The second phase was down-regulation of NE and designated as an adaptive effect which may be related to its antihypertensive effect. No adaptive effect on urinary E during medication was found. After withdrawal there was a significant rebound in NE and E, which might be the cause to lead to coronary accident in patients with severe ischaemic heart disease by acting on the hypersensitive beta-receptor in myocardium.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4730}
}