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Effect of the central action of propranolol on coronary circulation in dogs

  
@article{APS4713,
	author = {Bao-zhong Xie and Guo-jun Hu and Long-xing Yuan and Hong Wang and Wen-de Jiang},
	title = {Effect of the central action of propranolol on coronary circulation in dogs},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {In conscious dogs synchronized EEG pattern was demonstrated after intravenous(iv) or intracerebroventricular(icv) injections of dl-propranolol(dl-p),showing decreases of wave frequency and predominance of high amplitude slow waves. This suggests that dl-p blocked the beta-recetors in CNS. Dextroisomer(d-p),however, lacked such a central effect. In aneasthetized dogs the coronary blood flow was significantly decreased by both iv and icv dl-p, but d-p in neither routes showed significant effects. The possible relation between the central and coronary circulatory effects of dl-p was suggested.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4713}
}