@article{APS4712,
author = {Xian-gang Zong and Man-wen Jin and Ding-yuan Zhao and Chong-jia Hu and Fu-hua LV},
title = {Effects of dauricine on electrical and mechanical activities in the isolated guinea pig myocardium},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {1},
year = {2016},
keywords = {},
abstract = {The effects of dauricine(Dau) on electrical and mechanical activity were investigated in auricle and papillary muscle from guinea pigs. Dau 0.1 mM which reduced the force of contraction by 73.6% decreased the amplitude and dV/dtmax of action potential by 24.5% and 73.4%,respectively. Dau(1-300 microM) incaresed the duration of action potential(APD) to 20% and 90% repolarization and functional refractory period in a concentration-dependent way. But dV/dtmax of action potential and force of contraction were reduced almost equally by Dau also in a concentration-dependent manner. The effect that acetylcholine 30 microM shortened the APD of auricles was antagonized by Dau 30 microM. The effects of Dau can be explained by a non-specific inhibition of the current of Na+, Ca+ and K+.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4712}
}