@article{APS4706,
author = {Rong-xin Zhu and Li-ping Wang and Ting-chong Zhou},
title = {Change in the ATP content of the earthworm dorsal muscle during soman poisoning},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {1},
year = {2016},
keywords = {},
abstract = {Luciferase-luciferin method was used in the assay of ATP extracted with 6% n-butanol from the earthworm(Eisenia foetida) dordal muscle.ATP content in the dorsal muscle of intact earthworm poisoned by various concentrations of soman was present a good dose-dependent fashion.When 1.5 microg/mL soman was used, muscle ATP reduced to one-half of the normal value, whereas no ATP was found in the bathing medium. Ammonium sulfate and flunazepam, although caused muscular contraction, were noting to do with the ATP level. Experiments with serine, neostigmine and cobra venom suggested that ATP efflux probably closely related to Ach release. Cobra venom(25 microg/mL),but not scopolamine, maintained ATP within the normal level.It indicated that N-ChR action of the earthworm dorsal muscle is involved in the above-mentioned reaction.Adenosine 1 Mm suppressed ATP release through inhibition of Ach liberation which might be the mechanisim for the protective effect of adenosine on the ATP content of dorsal muscle during soman poisoning.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4706}
}