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Selectivity of [D-Ala2-O-benzyl-Ser5]-enkephalin on mu and delta opiate receptor subtypes

   
@article{APS4705,
	author = {Xin-quan Ji and Hong-liang Zhang and Su Liu and Gang Zou},
	title = {Selectivity of [D-Ala2-O-benzyl-Ser5]-enkephalin on mu and delta opiate receptor subtypes},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The selectively of [D-Ala2-O-benzyl-Ser5]- enkephalin(DABS) on mu and delta opiate receptor subtypes was studied by competing the binding of [3H] DADLE to the P2 fraction of the guinea pig brain homogenate and compared with mu agonist morphine and FW34-569 and delta agonist DADLE. DABS showed a high affinity to both mu and delta subtypes with about 10 times higher affinity to delta subtype. Therefore, DABS is less selective than DADLE on delta subtype.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4705}
}