@article{APS4668,
author = {Qi-cai LONG and Qi-chao PAN},
title = {Pharmacokinetics of methotrexate in rabbits and six neoplastic patients},
journal = {Acta Pharmacologica Sinica},
volume = {5},
number = {2},
year = {2016},
keywords = {},
abstract = {Plasma concentrations of methotrexate in 6 cancer patients and 5 rabbits after iv were determined by microbiological method (filter paper disc on plate). The concentrationtime curves were shown to be of first linear kinetic pattern, three-comparment for patiens and two-compartment for rabbits. Plasma concentration of methotrexate capable to inhibit DNA biosynthesis lasted 12 h in all patients. In 5/6 patients, the plasma methotrexate concentrations that were higher than the toxic threshold did not reach 42 h (toxic threshold time). The excretion rate of methotrexate in rabbits was rather fast.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4668}
}