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Absorption, distribution and excretion of (carboxy-14C)bisbromoacetyl hexestrol

   
@article{APS4663,
	author = {Yi-he LING and Ze HUA and Shang-yuan SUN and You-yi LIANG},
	title = {Absorption, distribution and excretion of (carboxy-14C)bisbromoacetyl hexestrol},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Bisbromoacetyl hexestrol is a new antitumor agent. Mice were given intragastrically [carboxy-14C]bisbromoacetyl hexestrol 500 mg/kg, the radioactivity in blood detected on a moderate level up to 24 h. In rats treated ig with 250 mg/kg, the radioacticity in blood attained the peak at 6-8 h. The tissue distribution of 14C in mice bearing sarcoma 180 was high in liver and stomach, moderate in intestine, kidney, prostate, epididymis, tumor and spleen. A marked retention of 14C was found in both uterus and ovary. Following ig gavage of [carboxy-14C] bisbromoacetyl hexestrol in 48 h, recoveries of 14C in mice were 36% in urine and 37% in feces. Choledochostomized rats excreted about 40% of the 14C within 12 h. Thin layer chromatograohy revealed that the polarity of the metabolite was higher.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4663}
}