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Anti-arrhythmic effect of total saponins of Panax notoginseng

   
@article{APS4659,
	author = {Sai LIU and Jun-xiu CHEN},
	title = {Anti-arrhythmic effect of total saponins of Panax notoginseng},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Total saponins were extracted from the root of Panax notoginseng (Burk) F H Chen. It showed anti-arrhythmic effects on (1) chloroform-induced ventricular fibrillation in mice; (2) BaCl2-or aconitine-induced arrhythmia in rats; (3) epinephrine-induced arrhythmia in tabbits under chloroform; (4) centricular fibrillation threshold of rabbits. It antagonized isoprenaline-induced tachycardia non-cometitively. The slowing of beart rate was not influenced by atropine. It inhibited the excitability, automaticity and contractility of isolated guinea pig atria. The lengthening of A-H interval in electrogram of His bundle indicated that A-V nodal conduction velocity was decreased.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4659}
}