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Comparison of the effect of five antitumor drugs on the hemopoietic and P388 leukemic stem cells in mice

   
@article{APS4646,
	author = {Qi-xin ZHOU and Zhen-kun PAN and Jian-bo FENG and Rui HAN},
	title = {Comparison of the effect of five antitumor drugs on the hemopoietic and P388 leukemic stem cells in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The effects of 5 antitumor drugs on normal bone marrow colony-forming units in culture (NCFU-C) and P388 leukemic colony forming units in culture (LCFU-C) of mice were compared by agar diffusion chamber(ADC) technique. The dose-survival curves for both of the stem cells exposed to harringtonine(H), homoharringtonine(HH), partial synthetic harringtonine(PSH), and cyclophosphamide(CY) exhibited exponential forms. The values of the efficacy ratio:H 1.8, HH 3.5, PSH 4.7, and CY 5.7. In contrast, there was no clear dose-response relationship between the effects of arabinosylcytosine(Ara-C) on NCFU-C and LCFU-C at dosage of 125-1000 mg/kg; dose-survival curves for both of the stem cells were decreased to about 38% at 1g/kg.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4646}
}