@article{APS4634,
author = {Yu-rui Xi and Jin-hua Nie and Yu-xin Xu},
title = {Effect in vitro of furapyrimidone on adult worms and microfilariae of Brugia malayi},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {4},
year = {2016},
keywords = {},
abstract = {Furapyrimidone, 1-[(5-nitrofurayl-2) methyene amino]-tetrahydropyrimidine-2-one, is a new antifilarial agent discovered in China. Its effects on adult worms and microfilariae of periodic Brugia malayi were studied in calf serum-Tyrode solution (1:20) containing 0.5% glucose. Furapyrimidone was lethal to adult worms and microfilariae and suppressed ♀ worms to release microfilariae at 1 μg/ml. When adult worms were kept in a medium containing furapyrimidone 50 μg/ml, the worms gradually lost their motility and died after 20 h. When adult worms were placed in furapyrimidone 1 μg/ml, the release of microfilariae by ♀ worms was suppressed and the survival time of adult worms was much shorter than that of controls (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4634}
}